INGs are potential drug targets for cancer
| Autor: | Yongzhong Hou, Runyun Zhang, Jianhua Jin, Juanjuan Shi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Cell signaling Angiogenesis Antineoplastic Agents Cell Cycle Proteins Biology Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Neoplasms medicine Animals Humans Molecular Targeted Therapy Cell Proliferation Homeodomain Proteins Hematology Cell growth Tumor Suppressor Proteins Cancer General Medicine medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Oncology Tumor progression 030220 oncology & carcinogenesis Immunology Cancer cell Cancer research |
| Zdroj: | Journal of cancer research and clinical oncology. 143(2) |
| ISSN: | 1432-1335 |
| Popis: | The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer cell sensitivity for chemotherapy and radiotherapy, while clinical observations show that INGs are frequently lost in some types of cancers. The aim of the study was to summarize the recent progress regarding INGs regulating tumor progression. The literatures of INGs regulating tumor progression were searched and assayed. The regulating signaling pathways of ING1, ING2, ING3 or ING4 on tumor progression were shown. The mechanisms of INGs on tumor suppression were also assayed. This review better summarized the signaling mechanism of INGs on tumor suppression, which provides a candidate therapy strategy for cancers. |
| Databáze: | OpenAIRE |
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