The TEL gene and human leukemia
| Autor: | T. W. Mclean, D G Gilliland, Michael H. Tomasson, Todd R. Golub, M Carroll, Kimberly Stegmaier |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Acute promyelocytic leukemia
Cancer Research Leukemia Proto-Oncogene Proteins c-ets Helix-Loop-Helix Motifs Translocation Breakpoint Myeloid leukemia Chromosomal translocation Biology medicine.disease Fusion protein Pathogenesis DNA-Binding Proteins Repressor Proteins Oncology hemic and lymphatic diseases Acute myelomonocytic leukemia Genetics medicine Cancer research Eosinophilia Humans medicine.symptom Transcription Factors |
| Zdroj: | Biochimica et biophysica acta. 1288(1) |
| ISSN: | 0006-3002 |
| Popis: | Chromosomal translocations have provided valuable insights into the molecular mechanisms of leukemogenesis in humans. Examples of genes implicated in pathogenesis of hematologic malignancy by virtue of involvement in translocation breakpoints include the PML-RARa fusion associated with t(15;17) acute promyelocytic leukemia (APML, refs. 1–3), the AML1-ETO fusion associated with t(8;21) acute myeloid leukemia (AML, ref.4), the CBFs-MYHII fusion associated with inv(16) acute myelomonocytic leukemia and eosinophilia (5), and MLL fusions at 11q23 breakpoints with various fusion proteins associated with acute myeloid leukemias (6). |
| Databáze: | OpenAIRE |
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