Hyposalivation is prevalent in bariatric patients but improves after surgery
| Autor: | Maryam M. Alghamdi, Katherine J. P. Schwenger, Allan Okrainec, Tim Jackson, Yasaman Ghorbani, Johane P. Allard |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Canada medicine.medical_specialty Gastric Bypass 030209 endocrinology & metabolism Type 2 diabetes Oral health Xerostomia Body Mass Index 03 medical and health sciences 0302 clinical medicine medicine Humans Prospective Studies Prospective cohort study 2. Zero hunger business.industry nutritional and metabolic diseases Middle Aged Anthropometry University hospital medicine.disease Obesity Obesity Morbid 3. Good health Surgery Cross-Sectional Studies Diabetes Mellitus Type 2 Absolute neutrophil count Female 030211 gastroenterology & hepatology business Body mass index |
| Zdroj: | Surgery for Obesity and Related Diseases. 16:1407-1413 |
| ISSN: | 1550-7289 |
| DOI: | 10.1016/j.soard.2020.06.005 |
| Popis: | Background Obesity and type 2 diabetes can be associated with poor oral health. This can be because of hyposalivation leading to chronic oral inflammation (OI) and periodontal disease. Objective To assess the prevalence of hyposalivation and OI in individuals undergoing Roux-en-Y gastric bypass (RYGB) and determine the relationship with metabolic and anthropometric parameters before and after RYGB. Setting University hospital in Canada. Methods This was a cross-sectional and prospective cohort study of 59 patients undergoing RYGB from September 2015 to December 2019. Anthropometric, biochemical, and oral measurements were taken before surgery and 1 and 6 months post RYGB. Oral parameters included salivary flow rate and neutrophil count as marker of OI. Results Fifty-nine patients were enrolled with 29 completing this study. At baseline, the median age was 47 years and body mass index was 46.5 kg/m2, 52 (88.1%) were female and 14 individuals (23.7%) had type 2 diabetes; 54.2% (n = 32) of patients had hyposalivation and 13.6% (n = 8) had high neutrophil count. Patients with hyposalivation had significantly higher fasting glucose (5.7 mmol/L) compared with those without hyposalivation (5.2 mmol/L) but no difference was found between high versus low neutrophil count. At 6 months post RYGB, all variables except oral neutrophil count significantly improved. Hyposalivation persisted in 7 (24%) individuals. Conclusions In our bariatric patients, more than half the patients had hyposalivation before RYGB and this was associated with higher fasting glucose. Hyposalivation improved post RYGB in parallel with improvements in metabolic parameters but there was no change in OI. Increased salivation may reduce the risk of periodontal disease. |
| Databáze: | OpenAIRE |
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