An Exploratory Study of the Salivary Immunoglobulin A Responses to 1 Dose of a Norovirus Virus-Like Particle Candidate Vaccine in Healthy Adults
| Autor: | Frank Baehner, Cong Han, Paul M. Mendelman, Robert L. Atmar, Astrid Borkowski, Jakob P Cramer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Immunoglobulin A Adult Male Adolescent Genotype viruses 03 medical and health sciences Young Adult Major Articles and Brief Reports 0302 clinical medicine Blood serum Immune system fluids and secretions Immunogenicity Vaccine Antigen Immunity Immunology and Allergy Medicine Humans 030212 general & internal medicine Vaccines Virus-Like Particle Saliva biology business.industry Immunogenicity Norovirus Vaccination Viral Vaccines Middle Aged Immunity Humoral 030104 developmental biology Infectious Diseases Immunology biology.protein Blood Group Antigens Female Antibody business |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 |
| Popis: | As noroviruses are transmitted through the fecal-oral route, we investigated humoral and mucosal (salivary immunoglobulin A [IgA]) immune responses in a phase 2 trial of Takeda's bivalent norovirus virus-like particle (VLP) vaccine candidate in 50 healthy 18- to 49-year-olds. The vaccine had an acceptable tolerability profile and induced rapid, robust humoral immune responses after 1 intramuscular dose of vaccine candidate. Seroresponses were evident 8 days after vaccination as panimmunoglobulin, IgA, and histo-blood group antigen-blocking antibodies against both vaccine GI.1 and GII.4c genotypes. Salivary IgA levels were approximately 1000-fold lower than serum concentrations, and moderately or strongly correlated with the serum IgA titers at all time-points. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|