Immunoregulatory role of secretory leukocyte protease inhibitor in allergic asthma
| Autor: | Jingxuan Yang, Rafael Marino, Aihao Ding, Yong Zhong Xu, Thusanth Thuraisingam, Jennifer Henri, Danuta Radzioch, Guoan He, Pierre Camateros |
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| Rok vydání: | 2010 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Pulmonary and Respiratory Medicine medicine.medical_specialty Allergy medicine.medical_treatment Inflammation Immunoglobulin E 03 medical and health sciences 0302 clinical medicine Airway resistance Internal medicine medicine Immunology and Allergy 030304 developmental biology 0303 health sciences biology business.industry General Medicine Eosinophil medicine.disease 3. Good health Cytokine medicine.anatomical_structure Endocrinology 030228 respiratory system Poster Presentation Immunology biology.protein medicine.symptom lcsh:RC581-607 business SLPI Respiratory tract |
| Zdroj: | Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology Allergy, Asthma & Clinical Immunology, Vol 6, Iss Suppl 3, p P24 (2010) |
| ISSN: | 1710-1492 |
| Popis: | Results Allergic SLPI transgenic mice showed a significant decrease in airway resistance compared to wild-type mice (6.3 ± 1.1 vs. 8.0 ± 2.1 cm H20 × s/ml, p < 0.001), the same effect was observed with inflammatory cell infiltration, eosinophil percentage (24 ± 1.1% vs. 29 ± 2.3%, p < 0.001), goblet cells (6 ± 1.4 vs. 36 ± 4.0%, p < 0.001) in the lungs and IgE levels (2014.1 ± 309.2 vs. 4173.2 ± 685.6 ng/ml, p < 0.001) in plasma. Allergic SLPI knock-out mice displayed significantly higher values compared to wild-type mice. They include lung resistance (8.6 ± 2.7 vs. 6.6 ± 0.5 cm H20*s/ml, p < 0.001), inflammatory cell influx, eosinophils (36.0 ± 2.7 vs. 29.0 ± 1.5%, p < 0.001), goblet cells (40 ± 4.1 vs. 30 ± 1.4%, p < 0.001), cytokine levels in the lungs (p < 0.05) and plasma IgE levels (3598 ± 204.7 vs. 2763 ± 220.3 ng/ml, p < 0.001). Expression of SLPI decreased inflammation in the lungs, plasma IgE levels, and lung resistance, whereas the ablation of SLPI has the opposite effect. Treatment with resiquimod improved airway resistance and inflammation of the lungs in SLPI knockout and wild type, demonstrating that its effect is independent of the expression of SLPI. Conclusions SLPI plays an immunoregulatory role in the respiratory tract by reducing the inflammatory process and by improving lung physiology in a murine model of acute allergic asthma. |
| Databáze: | OpenAIRE |
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