Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats
Autor: | I. G. Komoltsev, I. P. Levshina, S. O. Frankevich, A. O. Manolova, N. I. Shirobokova, Natalia V. Gulyaeva, M. R. Novikova, A. A. Volkova |
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Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine Traumatic brain injury Hippocampus Hippocampal formation Epileptogenesis Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Seizures Brain Injuries Traumatic medicine Animals Humans Neuroinflammation Neocortex business.industry General Neuroscience Electroencephalography General Medicine medicine.disease Patient Discharge Pathophysiology Rats Disease Models Animal Electrophysiology 030104 developmental biology medicine.anatomical_structure Anesthesia business 030217 neurology & neurosurgery |
Zdroj: | Neuroscience Research. 166:42-54 |
ISSN: | 0168-0102 |
Popis: | Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). It consisted of 3 typical groups: a) rats with low baseline and high post-craniotomy SWD level; b)with constantly low both baseline and post-craniotomy SWD levels; c) constantly high both baseline and post-craniotomy SWD levels. Rats with augmented SWD occurrence after TBI demonstrated freezing episodes accompanying SWDs as well as increased anxiety-like behavior (difficulty of choosing). The discharges were definitely associated with sleep phases. The incidence of SWDs positively correlated with the area of glial activation in the neocortex but not in the hippocampus.The translational potential of the data is revealing new pathophysiological links between epileptiform activity appearance, direct cortical and distant hippocampal damage and anxiety-like behavior, putative early predictors of late posttraumatic pathology. |
Databáze: | OpenAIRE |
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