Primary Hyperparathyroidism is Associated With subclinical Peripheral Neural Alterations
| Autor: | Francisco Bandeira, Erik Trovão Diniz, Otávio Gomes Lins, Thyciara Fontenele Marques, Hildo Azevedo, Alexandre Medeiros Sampaio Januário, Érica Nogueira Bezerra Cavalcanti, Tiago Matos de Arruda, Kaisa Trovão Diniz |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Sensory Receptor Cells endocrine system diseases Endocrinology Diabetes and Metabolism Neural Conduction Urology Action Potentials Parathyroid hormone Severity of Illness Index Nerve conduction velocity Polyneuropathies Endocrinology Sural Nerve Internal medicine Peripheral Nervous System Electroneuronography medicine Humans Aged Subclinical infection Motor Neurons Hyperparathyroidism business.industry General Medicine Middle Aged Hyperparathyroidism Primary medicine.disease Median Nerve Compound muscle action potential Cross-Sectional Studies medicine.anatomical_structure Parathyroid Hormone Hypercalcemia Calcium Female Tibial Nerve business Primary hyperparathyroidism Sensory nerve |
| Zdroj: | Endocrine Practice. 19:219-225 |
| ISSN: | 1530-891X |
| DOI: | 10.4158/ep12207.or |
| Popis: | Some case reports have suggested primary hyperparathyroidism (PHPT) and peripheral polyneuropathy (PPN) are associated; however, there are no reports of studies examining this possible relationship. The aim of this study was to evaluate peripheral nerve conduction in subjects with PHPT.The study involved 17 patients with PHPT. Mean patient age was 60.5 ± 12.9 years, serum calcium concentration was 11.5 ± 1.0 mg/dL, and the serum parathyroid hormone (PTH) level was 315 ± 569 pg/dL. The control group comprised 17 individuals without PHPT. The mean age of controls was 60.8 ± 12.5 years and the serum calcium concentration was 9.8 ± 0.3 mg/dL. Motor and sensory nerve conduction was assessed by electroneurography (ENG).The following ENG parameters differed significantly between the PHPT and control groups: right (R) sural sensory nerve action potential conduction velocity (52.7 ± 6.3 m/s versus 58.0 ± 8.0 m/s; P = .041); R median compound muscle action potential (CMAP) amplitude (7.4 ± 1.6 mV versus 8.9 ± 1.7 mV; P = .002); R median CMAP latency (4.3 ± 1.2 ms versus 3.6 ± 0.6 ms; P = .032); R tibial CMAP latency (4.2 ± 1.1 ms versus 3.3 ± 0.4 ms; P = .001). The neurological examination was normal in all patients.Our data demonstrate an association between PHPT and peripheral neurological alterations, consistent with subclinical sensory-motor PPN. |
| Databáze: | OpenAIRE |
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