Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia
| Autor: | Yoshinao Oda, Kenichi Kohashi, Shouichi Ohga, Masataka Ishimura, Hidetoshi Takada, Jun Okamura, Tatsuro Tajiri, Yoshihisa Nagatoshi, Toshiro Hara |
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| Rok vydání: | 2007 |
| Předmět: |
Hepatoblastoma
Male Pathology medicine.medical_specialty Time Factors Liver tumor Malignancy Fatal Outcome Living Donors medicine Humans Aplastic anemia Bone Marrow Transplantation Transplantation business.industry Siblings Liver Neoplasms Bone marrow failure Anemia Aplastic medicine.disease digestive system diseases medicine.anatomical_structure Child Preschool Hepatocellular carcinoma Pediatrics Perinatology and Child Health Bone marrow Tomography X-Ray Computed business Follow-Up Studies |
| Zdroj: | Pediatric Transplantation. 11:945-949 |
| ISSN: | 1399-3046 1397-3142 |
| Popis: | A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after a conditioning with antithymocyte globulin and cyclophosphamide. He became a HBV carrier after BMT. Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor. Extremely high levels of alpha-fetoprotein indicated the clinical diagnosis of hepatoblastoma that might be the first report as post-BMT malignancy. The necropsy specimens revealed that the tumor was recipient cell-origin and showed the histopathological features of both hepatoblastoma and hepatocellular carcinoma. Prolonged mixed chimerism and hepatitis virus infection might induce a rare oncogenesis after non-irradiated conditioning. |
| Databáze: | OpenAIRE |
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