Dimethylthiourea reverses sepsis-induced pulmonary hypertension in piglets
| Autor: | Lori A Shook, Thomas H. Pauly, Marple Sl, Sandra J Horstman, Mark N. Gillespie |
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| Rok vydání: | 1990 |
| Předmět: |
Pulmonary Circulation
Thromboxane Swine medicine.medical_treatment Hypertension Pulmonary Partial Pressure Blood Pressure Sepsis chemistry.chemical_compound medicine.artery Streptococcal Infections medicine Animals Saline business.industry Thiourea General Medicine bacterial infections and mycoses medicine.disease Pulmonary hypertension Thromboxane B2 Oxygen Disease Models Animal Blood pressure chemistry Animals Newborn Anesthesia Pulmonary artery Arterial blood business |
| Zdroj: | The American journal of the medical sciences. 300(1) |
| ISSN: | 0002-9629 |
| Popis: | Dimethylthiourea (DMTU), a putative hydroxyl radical scavenger, attenuates thromboxane generation and pulmonary hypertension in the piglet model of group B streptococcal (GBS) sepsis. This study tested the hypothesis that DMTU reverses ongoing GBS-induced pulmonary hypertension coincident with decreased thromboxane production. Piglets (n = 15) received a 60 min infusion of GBS (10 8 efu/kg/min). Mean pulmonary artery pressure ( P - pa), arterial blood gases (ABGs), and thromboxane B 2 (TXB) levels were measured at 10 min intervals throughout the study. GBS infusion resulted in a marked increase in pulmonary artery pressure (mean ∆ P - pa = 31 mm Hg) and a significant decline in PaO 2 (mean = −80 torr) within 10 min of beginning the infusion. pH decreased from a mean of 7.47 to 7.37. DMTU, 750 mg/kg, or normal saline vehicle was infused over 10–15 min beginning 10 min after initiating GBS. P - pa decreased significantly within 10 min of DMTU infusion. Piglets receiving vehicle had a slow decline in P - pa. Piglets receiving DMTU also had an improvement in Pao 2 and showed no further drop in pH. Piglets receiving vehicle had no improvement in Pao 2 and demonstrated a continued decline in pH. TXB levels did not differ between the groups at any time interval. We conclude that DMTU can partially reverse GBS-induced pulmonary hypertension, but may function through mechanisms independent of thromboxane generation. |
| Databáze: | OpenAIRE |
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