Contrast-Enhanced Ultrasound Using Perfluorobutane-Containing Microbubbles in the Assessment of Liver Allograft Damage: An Exploratory Prospective Study
| Autor: | Hyeyoung Kim, Dong Ho Lee, Jae Young Lee, Kwang-Woong Lee, Nam-Joon Yi, Ju Hyeon Jeon, Ijin Joo, Kyung-Suk Suh |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Acoustics and Ultrasonics medicine.medical_treatment Biophysics Contrast Media Liver transplantation Sensitivity and Specificity 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Biopsy Parenchyma medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Ultrasonography Fluorocarbons Microbubbles Radiological and Ultrasound Technology medicine.diagnostic_test Perfluorobutane business.industry Ultrasound Middle Aged Allografts Image Enhancement Liver Transplantation Liver chemistry 030220 oncology & carcinogenesis Liver biopsy Female 030211 gastroenterology & hepatology Radiology business Nuclear medicine Contrast-enhanced ultrasound |
| Zdroj: | Ultrasound in Medicine & Biology. 43:621-628 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2016.11.012 |
| Popis: | This prospective study investigated the usefulness of contrast (perfluorobutane-containing microbubbles)-enhanced ultrasound in the non-invasive assessment of liver allograft damage. Forty-one liver recipients underwent contrast-enhanced ultrasound followed by a liver biopsy. The hepatic filling rate (time between the arrival of contrast agent in the right hepatic artery and the maximum intensity of hepatic parenchyma) and parenchymal intensity difference before and after instantaneous high-power emission in the Kupffer phase were measured. Patients with allograft damage had higher hepatic filling rates and lower parenchymal intensity differences than those without damage (42.0 ± 16.9 vs. 30.5 ± 7.7 s, p = 0.005; 6.1 ± 7.4 vs. 16.6 ± 16.1 dB, p = 0.047, respectively). In the diagnosis of liver allograft damage, hepatic filling rate and parenchymal intensity difference had sensitivities of 61.5% and 90.9% and specificities of 92.6% and 63.6% using cutoffs of >38.5 s and ≤10.3 dB, respectively. In conclusion, contrast-enhanced ultrasound may be a promising tool in the detection of liver allograft damage. |
| Databáze: | OpenAIRE |
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