Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder: A cross-sectional study
| Autor: | Masaru Mimura, Juri Saruta, Alex Hofer, Georg Kemmler, Takefumi Suzuki, Yuya Mizuno, Hiroyuki Uchida, Fabienne Wartelsteiner, Beatrice Frajo-Apor, W. Wolfgang Fleischhacker, Keiichi Tsukinoki |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent Cross-sectional study Psychological intervention Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Bipolar disorder Young adult Saliva Psychiatry Resilience (network) Prospective cohort study Biological Psychiatry Aged Middle Aged Resilience Psychological medicine.disease Confidence interval 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Schizophrenia Female Schizophrenic Psychology Psychology Biomarkers 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Schizophrenia Research. 175:148-153 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2016.04.047 |
| Popis: | The concept of resilience is relevant in understanding the heterogeneous outcomes noted in schizophrenia and bipolar disorder. However, clinical and biological correlates of resilience in these populations have rarely been investigated. We aimed to identify key correlates of subjective resilience in such patients using comprehensive assessments and to explore associations between resilience levels and peripheral biomarkers.180 subjects with DSM-IV schizophrenia, bipolar disorder, and healthy controls (60 per group) were included. Demographic and clinical variables were assessed by means of interview and various psychometric scales. Furthermore, blood and saliva samples were obtained for the assessment of brain-derived neurotrophic factor, adrenocorticotropic hormone, cortisol, high sensitivity C-reactive protein, and alpha-amylase levels. Cross-sectional associations with resilience, as assessed by the 25-item Resilience Scale were sought.Resilience Scale total scores were significantly higher in healthy individuals (130.1, 95% confidence intervals (CI): 124.8-135.4) compared to subjects with schizophrenia (109.9, 95% CI: 104.6-115.2, p0.001) and bipolar disorder (119.0, 95% CI: 113.8-124.3, p=0.012), while the difference between patient groups was non-significant (p=0.055). Self-esteem, spirituality, quality of life, and hopelessness were correlated with resilience in all three groups. In addition, internalized stigma and depression were relevant factors in the schizophrenia and bipolar disorder group, respectively. Correlations between resilience levels and peripheral biomarkers did not reach significance.Although causal relationships must be confirmed in prospective studies, our results have implications in developing psychological interventions to enhance resilience in patients with schizophrenia and bipolar disorder. The biological correlates of resilience in these populations warrant further investigations. |
| Databáze: | OpenAIRE |
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