Clinical benefit using sperm hyaluronic acid binding technique in ICSI cycles: a systematic review and meta-analysis
Autor: | Ronit Beck-Fruchter, Amir Weiss, Eliezer Shalev |
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Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Pregnancy Rate medicine.medical_treatment Biology Intracytoplasmic sperm injection Male infertility Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Human fertilization Pregnancy Hyaluronic acid medicine Humans Embryo Implantation Sperm Injections Intracytoplasmic Hyaluronic Acid reproductive and urinary physiology Sperm-Ovum Interactions 030219 obstetrics & reproductive medicine urogenital system Obstetrics and Gynecology Hyaluronic Acid Binding medicine.disease Oocyte Spermatozoa Sperm 030104 developmental biology medicine.anatomical_structure Reproductive Medicine chemistry Fertilization Female Embryo quality Developmental Biology |
Zdroj: | Reproductive BioMedicine Online. 32:286-298 |
ISSN: | 1472-6483 |
Popis: | The human oocyte is surrounded by hyaluronic acid, which acts as a natural selector of spermatozoa. Human sperm that express hyaluronic acid receptors and bind to hyaluronic acid have normal shape, minimal DNA fragmentation and low frequency of chromosomal aneuploidies. Use of hyaluronic acid binding assays in intracytoplasmic sperm injection (ICSI) cycles to improve clinical outcomes has been studied, although none of these studies had sufficient statistical power. In this systematic review and meta-analysis, electronic databases were searched up to June 2015 to identify studies of ICSI cycles in which spermatozoa able to bind hyaluronic acid was selected. The main outcomes were fertilization rate and clinical pregnancy rate. Secondary outcomes included cleavage rate, embryo quality, implantation rate, spontaneous abortion and live birth rate. Seven studies and 1437 cycles were included. Use of hyaluronic acid binding sperm selection technique yielded no improvement in fertilization and pregnancy rates. A meta-analysis of all available studies showed an improvement in embryo quality and implantation rate; an analysis of prospective studies only showed an improvement in embryo quality. Evidence does not support routine use of hyaluronic acid binding assays in all ICSI cycles. Identification of patients that might benefit from this technique needs further study. |
Databáze: | OpenAIRE |
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