LncRNA HOXA11-AS promotes vascular endothelial cell injury in atherosclerosis by regulating the miR-515-5p/ROCK1 axis

Autor:	Feng Gao, Xiao‐Chen Wang, Zhi‐Dan Luo, Guang‐Quan Hu, Meng‐Qing Ma, Yi Liang, Bang‐Long Xu, Xian‐He Lin
Rok vydání:	2021
Předmět:	Mice MicroRNAs rho-Associated Kinases Animals Endothelial Cells RNA Long Noncoding Cardiology and Cardiovascular Medicine Atherosclerosis Cell Proliferation
Zdroj:	ESC heart failure. 9(4)
ISSN:	2055-5822
Popis:	Long non-coding RNA HOXA11-AS participated in heart disease. In this study, we aim to evaluate the potential roles of HOXA11-AS in atherosclerosis and its underlying mechanisms.The expression levels of HOXA11-AS in ox-LDL-treated HUVECs and arch tissues of high-fat diet-fed ApoEHOXA11-AS contributed to atherosclerotic injuries by directly regulating the miR-515-5p/ROCK1 axis. This study provided new evidence that HOXA11-AS might be a candidate for atherosclerosis therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6f89ead5d7ff487bc78506c37d168c https://pubmed.ncbi.nlm.nih.gov/35578440 Zobrazit plný text záznamu Plný text