Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of juvenile rats
| Autor: | Alina M. Trofimova, Lev G. Magazanik, Aleksey V. Zaitsev, T. Yu. Postnikova |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Neural facilitation Hippocampus Status epilepticus Biology Hippocampal formation Synaptic Transmission General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Extracellular stimulation Status Epilepticus medicine Juvenile Animals Seizure activity Rats Wistar General Immunology and Microbiology General Medicine Rats 030104 developmental biology Synaptic plasticity Pentylenetetrazole medicine.symptom General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 477(1) |
| ISSN: | 1608-3105 |
| Popis: | We studied the effect of status epilepticus (SE) on short-term synaptic plasticity. The amplitudes of field potentials in response to extracellular stimulation of the Schaffer collaterals were recorded in hippocampal slices. Subtle modifications were revealed on day 1 after SE, whereas on days 3 and 7 we did not find any differences from the control. These data show that, one day after SE, the probability of a transmitter release in hippocampal synapses decreases that serves as a compensatory mechanism, which prevents seizure activity. |
| Databáze: | OpenAIRE |
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