| Autor: |
Yuang Wang, Baoquan Ding, Lin Han, Jianbing Liu, Xuehe Lu, Su Duan, Wantao Tang, Xiaohui Wu |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
ACS Applied Bio Materials. 4:7701-7707 |
| ISSN: |
2576-6422 |
| Popis: |
DNA-based nanogels have attracted much attention in the biomedical research field. Herein, we report a universal strategy for the fabrication of an aptamer-modified DNA tetrahedron (TET)-based nanogel for combined chemo/gene therapy of multidrug-resistant tumors. In our design, terminal extended antisense oligonucleotides (ASOs) are employed as the linker to co-assemble with two kinds of three-vertex extended TETs for the efficient construction of the DNA-based nanogel. With the incorporation of an active cell-targeting group (aptamer in one vertex of TET) and a controlled-release element (disulfide bridges in the terminals of ASOs), the functional DNA-based nanogel can achieve targeted cellular internalization and stimuli-responsive release of embedded ASOs. After loading with the chemodrug (doxorubicin (DOX), an intercalator of double-stranded DNA), the multifunctional DOX/Nanogel elicits efficient chemo/gene therapy of human MCF-7 breast tumor cells with DOX resistance (MCF-7R). This aptamer-modified DNA tetrahedron-based nanogel provides another strategy for intelligent drug delivery and combined tumor therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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