Copper-Catalyzed Benign and Efficient Oxidation of Tetrahydroisoquinolines and Dihydroisoquinolines Using Air as a Clean Oxidant

Autor:	Yun-Gang He, Tien Ha Trieu, Qi-Qi Fan, Xing-Liang Zhu, Xiao-Xin Shi, Feng-Lei Li, Bo Zheng
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	010405 organic chemistry Dimethyl sulfoxide General Chemical Engineering General Chemistry 010402 general chemistry 01 natural sciences Article 0104 chemical sciences Catalysis Atmosphere lcsh:Chemistry chemistry.chemical_compound chemistry lcsh:QD1-999 Copper catalyzed Organic chemistry Open air
Zdroj:	ACS Omega ACS Omega, Vol 3, Iss 7, Pp 8243-8252 (2018)
ISSN:	2470-1343
Popis:	A green chemical method for mild oxidation of 1,2,3,4-tetrahydroisoquinolines (THIQs) and 3,4-dihydroisoquinolines (DHIQs) has been developed using air (O2) as a clean oxidant. DHIQs and THIQs could be efficiently oxidized to isoquinolines in dimethyl sulfoxide at 25 °C under an open air atmosphere with CuBr2 (20 mol %) as the catalyst; different bases [NaOEt and/or 1,8-diazabicyclo[5,4,0]undec-7-ene] were used for the reaction according to the patterns of substituents (R1, R2).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6c020f2ae667d5d22bbb45429451b1 http://europepmc.org/articles/PMC6644811 Zobrazit plný text záznamu