Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity
| Autor: | Linda A. Antonucci, Tiziana Quarto, Maria Celeste Fasano, Leonardo Fazio, Marina Mancini, Rita Masellis, Elvira Brattico, Paolo Taurisano, Annamaria Porcelli, Giuseppe Blasi, Raffaella Romano, Barbara Gelao, Alessandro Bertolino, Karen Johanne Pallesen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotyping Techniques Brain activity and meditation Emotions Inferior frontal gyrus Audiology Neuropsychological Tests Polymorphism Single Nucleotide behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Dopamine receptor D2 medicine Humans 0501 psychology and cognitive sciences Facial expression Analysis of Variance Brain Mapping medicine.diagnostic_test Working memory Receptors Dopamine D2 General Neuroscience 05 social sciences Brain medicine.disease Magnetic Resonance Imaging Mood Acoustic Stimulation Schizophrenia Auditory Perception Female Psychology Functional magnetic resonance imaging 030217 neurology & neurosurgery Music Cognitive psychology |
| Zdroj: | Quarto, T, Fasano, M C, Taurisano, P, Fazio, L, Antonucci, L A, Gelao, B, Romano, R, Mancini, M, Porcelli, A, Masellis, R, Pallesen, K J, Bertolino, A, Blasi, G & Brattico, E 2017, ' Interaction between DRD2 variation and sound environment on mood and emotion-related brain activity ', Neuroscience, vol. 341, pp. 9-17 . https://doi.org/10.1016/j.neuroscience.2016.11.010 |
| Popis: | Sounds, like music and noise, are capable of reliably affecting individuals’ mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene ( DRD2 rs1076560, G > T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G = 26; G/T = 12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise. Individual variation in mood induction was assessed before and after the task. Results showed mood improvement after music exposure in DRD2 GG subjects and mood deterioration after noise exposure in GT subjects. Moreover, the music, as opposed to noise environment, decreased the striatal activity of GT subjects as well as the prefrontal activity of GG subjects while processing emotional faces. These findings suggest that genetic variability of dopamine receptors affects sound environment modulations of mood and emotion processing. |
| Databáze: | OpenAIRE |
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