Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs

Autor: Hung-Wei Cheng, Chih Sheng Chiang, Chin-Hao Hsu, San-Yuan Chen, Yen-Ho Lai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Drug
Cell Survival
medicine.medical_treatment
media_common.quotation_subject
lcsh:QR1-502
Antineoplastic Agents
Triple Negative Breast Neoplasms
02 engineering and technology
macromolecular substances
Pharmacology
01 natural sciences
Biochemistry
Article
lcsh:Microbiology
chemistry.chemical_compound
Drug Delivery Systems
Drug Stability
Polylactic Acid-Polyglycolic Acid Copolymer
fucoidan
Polysaccharides
Cell Line
Tumor
medicine
Zeta potential
Humans
docetaxel
drug delivery system
Particle Size
anticancer therapy/cancer treatment
Cytotoxicity
Molecular Biology
Cell Proliferation
media_common
010405 organic chemistry
Fucoidan
technology
industry
and agriculture
PLGA
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Delayed-Action Preparations
Drug delivery
Nanoparticles
Female
Nanocarriers
0210 nano-technology
Adjuvant
Zdroj: Biomolecules, Vol 10, Iss 970, p 970 (2020)
Biomolecules
Volume 10
Issue 7
Popis: Fucoidan, a natural sulfated polysaccharide, which can activate the immune response and lessen adverse effects, is expected to be an adjuvant agent in combination with chemotherapy. Using natural hydrophilic anticancer polysaccharides to simultaneously encapsulate hydrophobic anticancer drugs is feasible, and a reduced side effect can be achieved to amplify the therapeutic efficacy. In this study, a novel type of fucoidan-PLGA nanocarrier (FPN-DTX) was developed for the encapsulation of the hydrophobic anticancer drug, docetaxel (DTX), as a drug delivery system. From the comparison between FPN-DTX and the PLGA particles without fucoidan (PLGA-DTX), FPNs&ndash
DTX with fucoidan were highly stable with smaller sizes and dispersed well without aggregations in an aqueous environment. The drug loading and release can be further modified by modulating relative ratios of Fucoidan (Fu) to PLGA. The (FPN 3-DTX) nanoparticles with a 10:3 ratio of Fu:PLGA displayed uniform particle size with higher encapsulation efficiency than PLGA NPs and sustained drug release ability. The biocompatible fucoidan-PLGA nanoparticles displayed low cytotoxicity without drug loading after incubation with MDA-MB-231 triple-negative breast cancer cells. Despite lower cellular uptake than that of PLGA-DTX due to a higher degree of negative zeta potential and hydrophilicity, FPN 3-DTX effectively exerted better anticancer ability, so FPN 3-DTX can serve as a competent drug delivery system.
Databáze: OpenAIRE
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