Fast continuous alcohol amination employing a hydrogen borrowing protocol
| Autor: | Steven V. Ley, María José Nieves-Remacha, Claudio Battilocchio, Graham R. Cumming, Ricardo Labes, Paul Dingwall, Juan A. Rincón, Carlos Mateos, Yiding Chen |
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| Přispěvatelé: | Labes, Ricardo [0000-0003-4001-0775], Battilocchio, Claudio [0000-0002-4601-8527], Chen, Yiding [0000-0001-6932-9005], Dingwall, Paul [0000-0002-6961-7995], Ley, Steven [0000-0002-7816-0042], Apollo - University of Cambridge Repository |
| Rok vydání: | 2018 |
| Předmět: |
Hydrogen
34 Chemical Sciences 010405 organic chemistry chemistry.chemical_element Alcohol 3405 Organic Chemistry social sciences 010402 general chemistry 01 natural sciences Pollution Combinatorial chemistry 0104 chemical sciences Catalysis Solvent chemistry.chemical_compound chemistry Reagent Environmental Chemistry Methanol Dimethylamine Amination |
| DOI: | 10.17863/cam.34164 |
| Popis: | A continuous flow method for the direct conversion of alcohols to amines via a hydrogen borrowing approach is reported. The method utilises a low loading (0.5%) of a commercial catalyst system ([Ru(p-cymene)Cl2]2 and DPEPhos), reagent grade solvent and is selective for primary alcohols. Successful methylation of amines using methanol and the direct dimethylamination of alcohols using commercial dimethylamine solution are reported. The synthesis of two pharmaceutical agents Piribedil (5) and Buspirone (25) were accomplished in good yields employing these new methods. |
| Databáze: | OpenAIRE |
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