Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery
| Autor: | Sharmila Foulds, P. D. Carey, Pierre J. Guillou, C. H. Wakefield, John R. T. Monson |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors T-Lymphocytes T cell Antigen presentation Human leukocyte antigen Major histocompatibility complex Monocytes Sepsis Postoperative Complications Immune system medicine Humans Surgical Wound Infection Respiratory Tract Infections Aged Aged 80 and over MHC class II biology business.industry Monocyte Bacterial Infections HLA-DR Antigens Middle Aged medicine.disease Surgery medicine.anatomical_structure Antibody Formation Immunology biology.protein Female business |
| Zdroj: | British Journal of Surgery. 80:205-209 |
| ISSN: | 1365-2168 0007-1323 |
| Popis: | Expression of class II major histocompatibility complex (MHC) on monocytes is a prerequisite for effective antigen presentation and processing, an important component of the immune response to infection. It has been reported that the level of monocyte class II expression may identify patients who go on to develop infective complications following trauma. In the present study, flow cytometry was used to measure MHC class II (human leucocyte antigen (HLA)-DR) expression on circulating monocytes and T cells in 36 patients undergoing elective major resectional surgery, of whom 12 developed septic complications. The percentage of HLA-DR positive monocytes fell significantly on the first day after operation in both groups (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text