Ductal Lavage for Detection of Cellular Atypia in Women at High Risk for Breast Cancer
| Autor: | Susan M. Love, Eileen B. King, John N. Quiring, Patricia A. Ganz, David M. Euhus, Raquel D. Arias, Seema A. Khan, Mark C. Kelley, Bonnie L. King, P. J. Schmit, David T. Hung, Susan Troyan, William C. Dooley, Umberto Veronesi, Britt-Marie Ljung, Rogsbert F. Phillips, Massimiliano Cazzaniga, David L. Page, Ramona R. Clark, Joyce O'Shaughnessy, Richard M. Elledge, Bruce G. Haffty, Benjamin O. Anderson, Maxine M. Anderson, Laura J. Esserman, Frederic C. Kass, Henry M. Kuerer |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Ductal lavage Ductal cells Cytodiagnosis Mammary gland Breast Neoplasms Breast cancer Nipple Aspirate Fluid medicine Humans Breast Prospective Studies Therapeutic Irrigation skin and connective tissue diseases Aged Aged 80 and over business.industry Biopsy Needle Middle Aged medicine.disease medicine.anatomical_structure Nipple Discharge Aspiration Oncology Female business Random Periareolar Fine-Needle Aspiration Galactography |
| Zdroj: | JNCI Journal of the National Cancer Institute. 93:1624-1632 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/93.21.1624 |
| Popis: | Background: Breast cancer originates in breast epithelium and is associated with progressive molecular and morphologic changes. Women with atypical breast ductal epithelial cells have an increased relative risk of breast cancer. In this study, ductal lavage, a new procedure for collecting ductal cells with a microcatheter, was compared with nipple aspiration with regard to safety, tolerability, and the ability to detect abnormal breast epithelial cells. Methods: Women at high risk for breast cancer who had nonsuspicious mammograms and clinical breast examinations underwent nipple aspiration followed by lavage of fluid-yielding ducts. All statistical tests were two-sided. Results: The 507 women enrolled included 291 (57%) with a history of breast cancer and 199 (39%) with a 5-year Gail risk for breast cancer of 1.7% or more. Nipple aspirate fluid (NAF) samples were evaluated cytologically for 417 women, and ductal lavage samples were evaluated for 383 women. Adequate samples for diagnosis were collected from 111 (27%) and 299 (78%) women, respectively. A median of 13500 epithelial cells per duct (range, 43-492 000 cells) was collected by ductal lavage compared with a median of 120 epithelial cells per breast (range, 10-74300) collected by nipple aspiration. For ductal lavage, 92 (24%) subjects had abnormal cells that were mildly (17%) or markedly (6%) atypical or malignant ( |
| Databáze: | OpenAIRE |
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