An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells
| Autor: | George Coukos, Arnan Mitchell, Khashayar Khoshmanesh, Xiaokang Li, Hatice Altug, Crispin Szydzik, Maria Soler, Alexander Belushkin, Julien Schmidt, Filiz Yesilkoy |
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| Rok vydání: | 2019 |
| Předmět: |
extraordinary optical-transmission
Cell Microfluidics microfluidics fabrication macromolecular substances 02 engineering and technology label-free 03 medical and health sciences Single-cell analysis medicine single-cell analysis Secretion Fluid regulation 030304 developmental biology Label free 0303 health sciences Chemistry pdms technology industry and agriculture nanoplasmonics 021001 nanoscience & nanotechnology Cell biology medicine.anatomical_structure Cytokine secretion 0210 nano-technology Biosensor |
| Zdroj: | PRIME |
| DOI: | 10.1109/prime.2019.8787840 |
| Popis: | An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubation and fluid regulation for stable live cell monitoring. Different spatiotemporal profiles of interleukin-2 secretion were observed from single lymphoma cells. This novel configuration of label-free biosensor is promising for single-cell related studies. |
| Databáze: | OpenAIRE |
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