Optimization and Validation of a Facile RP-HPLC Method for Determination of Betrixaban and Lercanidipine in Pharmaceutical and Biological Matrices

Autor:	Abdallah M. Zeid, Ihsan A. Shehata, Amal A. El-Masry, Dalia R. El-Wasseef, Manal Eid
Rok vydání:	2021
Předmět:	Dihydropyridines Analyte Pyridines Relative standard deviation 01 natural sciences Analytical Chemistry chemistry.chemical_compound Limit of Detection medicine Humans Triethylamine Chromatography High Pressure Liquid Detection limit Chromatography 010405 organic chemistry Lercanidipine 010401 analytical chemistry Reproducibility of Results General Medicine 0104 chemical sciences Chromatographic separation Pharmaceutical Preparations chemistry Betrixaban Benzamides Oral anticoagulant medicine.drug
Zdroj:	Journal of Chromatographic Science. 59:785-794
ISSN:	1945-239X 0021-9665
DOI:	10.1093/chromsci/bmab088
Popis:	A simple, accurate, rapid and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method was established for determination of a novel non-vitamin K antagonist oral anticoagulant drug, betrixaban, and its co-administered calcium-channel blocker drug, lercanidipine, in pharmaceutical formulations and biological fluids. The proposed HPLC method was the first chromatographic method applied to estimate this mixture in a short chromatographic run (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed618654ea67adbeb678f88168f75fd1 https://doi.org/10.1093/chromsci/bmab088 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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