Simultaneous emergence and rapid spread of three OXA-23 producing Acinetobacter baumannii ST208 strains in intensive care units confirmed by whole genome sequencing
| Autor: | Jian-zhong Fan, Jia-wei Zhou, Dao-jun Yu, Yan Jiang, Xian-jun Wang, Sheng-hai Wu, Lihui Xu, Qiong Chen, Zhi Ruan, Yunsong Yu |
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| Rok vydání: | 2018 |
| Předmět: |
Acinetobacter baumannii
Male 0301 basic medicine Microbiology (medical) 030106 microbiology Single-nucleotide polymorphism Microbial Sensitivity Tests Biology Polymorphism Single Nucleotide Microbiology Genome beta-Lactamases Disease Outbreaks 03 medical and health sciences Intensive care Genetics Humans Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics Aged Retrospective Studies Aged 80 and over Whole genome sequencing Whole Genome Sequencing Phylogenetic tree Transmission (medicine) Outbreak Middle Aged biology.organism_classification Intensive Care Units Infectious Diseases Female Genome Bacterial Acinetobacter Infections |
| Zdroj: | Infection, Genetics and Evolution. 58:243-250 |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2018.01.005 |
| Popis: | Carbapenem-resistant Acinetobacter baumannii (CRAB) is a common nosocomial bacterial pathogen with limited treatment options. CRAB outbreaks are disastrous for critically ill patients. This study investigated carbapenemase-produced A. baumannii outbreaks in a tertiary hospital. Although multiple outbreaks were suggested by pulse-field gel electrophoresis, the genetic lineages and evolution between these isolates were not clear. To investigate the genomic epidemiology of these outbreaks and to reveal possible transmission routes, whole genome sequences (WGS) were compared and analyzed. From the WGS data, thirty isolates had the same sequence type (ST208); acquired resistance genes and chromosome resistant genes were detected and were responsible for multidrug resistance. A phylogenetic tree of single-nucleotide polymorphisms (SNPs) compared to the earliest index isolate found that three outbreaks had emerged and disseminated simultaneously. Of these |
| Databáze: | OpenAIRE |
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