Blood group O is associated with post-COVID-19 syndrome in outpatients with a low comorbidity index

Autor: Sara Díaz-Salazar, Raquel Navas, Laura Sainz-Maza, Patricia Fierro, Meryam Maamar, Arancha Artime, Héctor Basterrechea, Benedetta Petitta, Stefanie Pini, José Manuel Olmos, Carmen Ramos, Emilio Pariente, José Luis Hernández
Rok vydání: 2022
Předmět:
Zdroj: Infectious diseases (London, England). 54(12)
ISSN: 2374-4243
Popis: ABO blood group system modulates the inflammatory response and has been implicated in COVID-19. Group O protects against SARS-CoV-2 infection, but there are no data regarding post-COVID-19 syndrome (PCS). Our aim was to assess this possible association.Case-control study in a community setting, with subjects who had experienced mild COVID-19. Cases were PCS+, controls were PCS-, and the exposure variable, group O. We collected age, sex, BMI, smoking, comorbidities, inflammatory markers, anti-SARS-CoV-2 IgG antibodies, blood type and clinical data. Five composite inflammatory indices were developed. Multivariate analyses were performed.We analysed 121 subjects (56.2% women), mean age 45.7 ± 16 years. Blood group frequencies were 41.5%, 7.9%, 5.9%, and 44.5% for A, B, AB and O, respectively. Thirty-six patients were PCS+, without significant differences between cases and controls. Compared to non-O, a higher prevalence of PCS (Group O has shown a consistent relationship with PCS, characterised by a more intense inflammatory burden than the other blood groups. Blood group O could be part of the immunological link between acute COVID-19 and PCS.
Databáze: OpenAIRE
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