Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration
Autor: | Ursula Schmidt-Erfurth, Stefan Sacu, Andreas Pollreisz, Guenther Weigert, Katharina Eibenberger, Alexander Hecht, Sandra Rezar-Dreindl, Reinhard Told, Ferdinand Georg Schlanitz, Maria Elisabeth Kroh, Magdalena Baratsits |
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Rok vydání: | 2018 |
Předmět: |
Indocyanine Green
Male medicine.medical_specialty Visual acuity genetic structures Intraclass correlation Fundus Oculi media_common.quotation_subject Visual Acuity Lesion 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Contrast (vision) Humans Macula Lutea Prospective Studies Fluorescein Angiography Prospective cohort study Coloring Agents media_common Aged Aged 80 and over medicine.diagnostic_test business.industry Reproducibility of Results Macular degeneration Middle Aged Fluorescein angiography medicine.disease eye diseases Choroidal neovascularization 030221 ophthalmology & optometry Wet Macular Degeneration Female sense organs medicine.symptom business 030217 neurology & neurosurgery Tomography Optical Coherence Follow-Up Studies |
Zdroj: | Investigative ophthalmologyvisual science. 59(6) |
ISSN: | 1552-5783 |
Popis: | Purpose The purpose of this study is to compare the ability of spectral domain optical coherence tomography angiography (SD-OCTA) and indocyanine green angiography (ICGA) to detect and measure lesion area in patients with type 1 and 2 choroidal neovascularization (CNV). Methods Types 1 and 2 neovascular AMD (nAMD) were included in this prospective and observational case series. ETDRS best-corrected visual acuity (BCVA), ophthalmic examination with funduscopy, OCTA (AngioVue), fluorescein angiography (FA), ICGA, and OCT (Spectralis) were performed. CNV measurements were done manually by two experienced graders using the systems' innate region selection tools. Results Forty eyes of 39 consecutive patients with nAMD were included. Mean age was 77 ± 6.4 years, ETDRS BCVA was 67 ± 13 letters, and 11 eyes were treatment naive. Nineteen CNV lesions were classified as type 1 and 21 as type 2. ICGA was able to identify CNV in all eyes. By contrast, OCTA detected CNV in 95% of type 1 and 86% of type 2 nAMD eyes. Mean overall CNV area (CNV-A) was 2.8 ± 2.7 mm2 in ICGA and 2.1 ± 2.7 mm2 in OCTA. Both lesion types CNV-A appeared significantly smaller in OCTA compared with ICGA (P < 0.01). Bland-Altman plot revealed a mean difference (bias) between OCTA and ICGA CNV-A of 0.76 ± 1.74 mm2. Intraclass correlation coefficient (ICC) for CNV-A was 0.91 and 0.93 for ICGA and OCTA, respectively. ICGA CNV-A in the four OCTA-negative eyes (median 4.7 mm2) was not significantly different from the 36 OCTA-positive eyes (median 1.7 mm2). Conclusions Type 1 and 2 CNV-A were significantly smaller in OCTA than in ICGA. OCTA was generally less successful in detecting CNV than ICGA in patients who were included into this study based on FA and OCT. However, OCTA detected all type 1 lesions except for one, indicating that the SD-OCTA signal is limited by detection limits of blood flow velocity rather than lesion type. Further efforts are needed pushing the limits of lowest detectable and fastest distinguishable flow until OCTA can deliver realistic qualitative and quantitative imaging of type 1 and 2 CNV for diagnosis and monitoring. |
Databáze: | OpenAIRE |
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