Sex Differences in Systolic Heart Failure in the Elderly: The Prognostic Importance of Left Ventricular Mass in Women
| Autor: | Hans Persson, Magnus Edner, Märit Mejhert, Thomas Kahan |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Systole Heart Ventricles New York Hemodynamics Comorbidity Risk Assessment Severity of Illness Index Ventricular Dysfunction Left Internal medicine medicine Humans Mass index Prospective Studies Sex Distribution Ventricular remodeling Prospective cohort study Aged Proportional Hazards Models Heart Failure Ejection fraction Ventricular Remodeling business.industry General Medicine Middle Aged Prognosis medicine.disease Blood chemistry Echocardiography Heart failure Cardiology Female business Follow-Up Studies |
| Zdroj: | Journal of Women's Health. 17:373-381 |
| ISSN: | 1931-843X 1540-9996 |
| DOI: | 10.1089/jwh.2007.0487 |
| Popis: | We investigated the hypothesis that there are prognostic differences in the importance of left ventricular (LV) mass and function between male and female patients hospitalized with heart failure.Patientsor =60 years old hospitalized with New York Heart Association class II-IV heart failure and LV systolic dysfunction were prospectively followed foror =18 months. At study start, a physical examination and echocardiography were performed, and blood chemistry samples were obtained.Of 158 patients, 66 (42%) women were included and were followed for a mean of 3.1 years. The women were older (77 +/- 7 vs. 74 +/- 7 years, p0.01) and had lower mortality (24% vs. 43%, p0.05) than the men. No gender differences in etiology or medication were found. LV mass index (LVMI 132 +/- 42 vs. 156 +/- 21 g/m(2), p0.01) was lower in women. Mortality in women was related to lower LV ejection fraction, larger LV volumes, and higher LVMI (all p0.05). In multivariate analysis, LVMI was the strongest independent mortality predictor in women (adjusted hazard ratio [HR] LMVI125 g/m(2) 7.4 [1.5-35.5], p = 0.01), whereas this association was not found in men.In patients hospitalized with systolic heart failure, women had lower mortality than men. In women, an increased LVMI was a stronger predictor of mortality than traditional measures of LV size and function. LVMI should be considered for assessment of prognosis in women with heart failure. |
| Databáze: | OpenAIRE |
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