Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing
| Autor: | Ping Zhou, ZhouXue Wu, Yue Li, Kang Xiong, XianLun Pang, Yun Lu, ShaoZhi Fu, Ling Zhao, BiQiong Wang, QingQing Leng |
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| Rok vydání: | 2020 |
| Předmět: |
Male
collagen Staphylococcus aureus medicine.medical_specialty Materials science Composite number Pharmaceutical Science Nanoparticle Biocompatible Materials wound healing Composite film Microbial Sensitivity Tests RM1-950 02 engineering and technology 030226 pharmacology & pharmacy Epithelium Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Escherichia coli pva medicine Animals curcumin Skin Skin repair integumentary system General Medicine 021001 nanoscience & nanotechnology Bandages Anti-Bacterial Agents Rats composite film Drug Liberation Plastic surgery chemistry Polyvinyl Alcohol Wound dressing Curcumin nanoparticles Therapeutics. Pharmacology 0210 nano-technology Wound healing Hair Follicle Research Article Biomedical engineering |
| Zdroj: | Drug Delivery, Vol 27, Iss 1, Pp 1676-1685 (2020) Drug Delivery article-version (VoR) Version of Record |
| ISSN: | 1521-0464 1071-7544 |
| DOI: | 10.1080/10717544.2020.1853280 |
| Popis: | Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson’s trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects. |
| Databáze: | OpenAIRE |
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