Sensitivity and specificity of an electronic nose in diagnosing pulmonary tuberculosis among patients with suspected tuberculosis

Autor: Yanri Wijayanti Subronto, Ning Rintiswati, Jan-Willem Gerritsen, Tjip S. van der Werf, Onno W. Akkerman, Ymkje Stienstra, Antonia Morita Iswari Saktiawati, Sumardi, Henny Oord
Přispěvatelé: Microbes in Health and Disease (MHD)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Bacterial Diseases
Pulmonology
Physiology
environment and public health
0302 clinical medicine
Medicine and Health Sciences
030212 general & internal medicine
Electronic Nose
Multidisciplinary
biology
medicine.diagnostic_test
integumentary system
Organic Compounds
BACTEC MGIT 960
MYCOBACTERIA
Middle Aged
RECOVERY
Body Fluids
Actinobacteria
Chemistry
Infectious Diseases
Breath Tests
Physical Sciences
Medicine
Tuberculosis Diagnosis and Management
Female
medicine.symptom
Anatomy
Research Article
Adult
medicine.medical_specialty
Tuberculosis
Adolescent
Science
Point-of-Care Systems
Chronic Obstructive Pulmonary Disease
LOWENSTEIN-JENSEN MEDIUM
Sensitivity and Specificity
Mycobacterium tuberculosis
03 medical and health sciences
Young Adult
Diagnostic Medicine
Internal medicine
medicine
Humans
Tuberculosis
Pulmonary
Asthma
Aged
Breath test
Volatile Organic Compounds
Receiver operating characteristic
Bacteria
business.industry
Organic Chemistry
Case-control study
Sputum
Organisms
Chemical Compounds
Biology and Life Sciences
biology.organism_classification
medicine.disease
Tropical Diseases
Mucus
030228 respiratory system
ROC Curve
Indonesia
DISCRIMINATION
Case-Control Studies
business
Body mass index
Mycobacterium Tuberculosis
SYSTEM
Zdroj: PLoS ONE, 14(6):0217963. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217963 (2019)
ISSN: 1932-6203
Popis: OBJECTIVE: To investigate the potency of a hand-held point-of-care electronic-nose to diagnose pulmonary tuberculosis (PTB) among those suspected of PTB.METHODS: Setting: Lung clinics and Dr. Sardjito Hospital, Yogyakarta, Indonesia. Participants: patients with suspected PTB and healthy controls. Sampling: 5 minutes exhaled breath. Sputum-smear-microscopy, culture, chest-radiography, and follow-up for 1.5-2.5 years, were used to classify patients with suspected PTB as active PTB, probably active PTB, probably no PTB, and no PTB. After building a breath model based on active PTB, no PTB, and healthy controls (Calibration phase), we validated the model in all patients with suspected PTB (Validation phase). In each variable (sex, age, Body Mass Index, co-morbidities, smoking status, consumption of alcohol, use of antibiotics, flu symptoms, stress, food and drink intake), one stratum's Receiver Operating Characteristic (ROC)-curve indicating sensitivity and specificity of the breath test was compared with another stratum's ROC-curve. Differences between Area-under-the-Curve between strata (pRESULTS: Of 400 enrolled participants, 73 were excluded due to extra-pulmonary TB, incomplete data, previous TB, and cancer. Calibration phase involved 182 subjects, and the result was validated in 287 subjects. Sensitivity was 85% (95%CI: 75-92%) and 78% (95%CI: 70-85%), specificity was 55% (95%CI: 44-65%) and 42% (95%CI: 34-50%), in calibration and validation phases, respectively. Test sensitivity and specificity were lower in men.CONCLUSION: The electronic-nose showed modest sensitivity and low specificity among patients with suspected PTB. To improve the sensitivity, a larger calibration group needs to be involved. With its portable form, it could be used for TB screening in remote rural areas and health care settings.
Databáze: OpenAIRE
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