Functional deficiency of antigen-presenting cells in the synovial fluid of rheumatoid arthritis
| Autor: | Eduardo Egea, Marcela Salazar, Antonio Iglesias, E.J. Yunis, Patricia A. Fraser, Devendra P. Dubey, Harold Deulofeut |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Pathology medicine.medical_specialty T-Lymphocytes Immunology Antigen presentation Antigen-Presenting Cells Arthritis Lymphocyte Activation Immunophenotyping Arthritis Rheumatoid Antigen HLA Antigens Synovial Fluid Cell Adhesion Tetanus Toxoid Humans Immunology and Allergy Medicine Synovial fluid Phytohemagglutinins Antigen-presenting cell Aged Aged 80 and over Immunity Cellular business.industry General Medicine Middle Aged medicine.disease Pokeweed Mitogens Synovial Cell Rheumatoid arthritis Prednisone Female business |
| Zdroj: | Human Immunology. 35:109-115 |
| ISSN: | 0198-8859 |
| Popis: | In our study of rheumatoid arthritis (RA) patients, we observed a decrease of tetanus toxoid antigen-presenting capacity of synovial fluid (SF) adherent cells to autologous T cells of either SF or peripheral blood. Additionally, we found a higher capacity of adherent synovial cells to stimulate autologous T-lymphocytes. Our results suggest that antigen-presenting cells of the SF of RA patients have defects that may play a role in defective presentation of antigens in joints and may account for other abnormal functions important in the pathogenesis of RA. |
| Databáze: | OpenAIRE |
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