The prognostic role of IL-10 in non-severe COVID-19 with chemosensory dysfunction
| Autor: | Iacopo Vellere, Oreste Gallo, Maria Cilona, Matteo Piccica, Chiara Bruno, Giuseppe Fancello, Giandomenico Maggiore, Luca Giovanni Locatello, Filippo Lagi, Pietro Orlando, Michele Trotta |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Short Communication Immunology Biochemistry Gastroenterology Severity of Illness Index Pathogenesis Cohort Studies 03 medical and health sciences Olfaction Disorders Taste Disorders 0302 clinical medicine Interleukin 10 Full recovery Recovery Internal medicine Severity of illness Immunology and Allergy Medicine Humans Molecular Biology Pandemics business.industry SARS-CoV-2 Respiratory disease COVID-19 Hematology Recovery of Function Middle Aged medicine.disease Prognosis Interleukin-10 Smell 030104 developmental biology 030220 oncology & carcinogenesis Taste Cohort Female Inflammation Mediators business Biomarkers Cohort study |
| Zdroj: | Cytokine |
| ISSN: | 1096-0023 |
| Popis: | Objectives Olfactory and gustatory dysfunction (OD/GD) are now recognized as typical symptoms of COVID-19 infection. However, their pathogenesis remains unclear and no clear prognostic factors have been identified. We have analyzed a cohort of mild/moderate hospitalized patients to identify possible clinical or immunological predictors of recovery from OD/GD. Methods Clinical and biological parameters were reviewed along with associated comorbidities. Chemosensory Complaint Score was administered on admission and 30 days after the first negative swab. Unpaired Wilcoxon and chi-squared tests were used to compare the variables in the patients who recovered versus those who did not. Results From a cohort of 119 hospitalized patients, 43 (36%) reported OD/GD on admission. 60.6% had a full recovery from OD and 69.2% from GD. Only the concentration of IL-10 on admission emerged as significantly associated with recovery of taste (p = 0.041) while allergic respiratory disease was more prevalent in the group who did not recover from OD (p = 0.049) and GD (p = 0.007). Conclusion These findings suggest that COVID-19 associated OD/GD is an inflammatory-mediated condition and that clinical and immunological parameters could predict the evolution of these symptoms. |
| Databáze: | OpenAIRE |
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