Neurocardiovascular coupling in congenital diaphragmatic hernia patients undergoing different types of surgical treatment
| Autor: | Katrin Zahn, Sophie A Costerus, Jurgen C. de Graaff, Alexander Caicedo Dorado, Rene M. H. Wijnen, Dick Tibboel, Sabine Van Huffel, Dries Hendrikx, Alba Perez-Ortiz, Gunnar Naulaers, Lucas Wessel |
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| Přispěvatelé: | Pediatric Surgery, Anesthesiology |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Neonatal intensive care unit
SURGERY OPEN REPAIR NEONATAL CRITICAL ILLNESS Anesthesiology medicine Clinical endpoint Humans Prospective Studies Cerebral perfusion pressure LABEL DRUG-USE Prospective cohort study RISK Science & Technology business.industry Thoracoscopy Infant Newborn Congenital diaphragmatic hernia MIDAZOLAM medicine.disease Pathophysiology VARIABILITY Treatment Outcome Anesthesiology and Pain Medicine Cerebral blood flow Cerebrovascular Circulation Anesthesia INFORMATION-TRANSFER Midazolam CDH Hernias Diaphragmatic Congenital business Life Sciences & Biomedicine medicine.drug |
| Zdroj: | European Journal of Anaesthesiology, 39(8), 662-672. Lippincott Williams & Wilkins |
| ISSN: | 0265-0215 |
| DOI: | 10.1097/eja.0000000000001642 |
| Popis: | BACKGROUND: The effect of peri-operative management on the neonatal brain is largely unknown. Triggers for perioperative brain injury might be revealed by studying changes in neonatal physiology peri-operatively. OBJECTIVE: To study neonatal pathophysiology and cerebral blood flow regulation peri-operatively using the neuro-cardiovascular graph. DESIGN: Observational, prospective cohort study on perioperative neuromonitoring. Neonates were included between July 2018 and April 2020. SETTING: Multicentre study in two high-volume tertiary university hospitals. PATIENTS: Neonates with congenital diaphragmatic hernia were eligible if they received surgical treatment within the first 28 days of life. Exclusion criteria were major cardiac or chromosomal anomalies, or syndromes associated with altered cerebral perfusion or major neurodevelopmental impairment. The neonates were stratified into different groups by type of peri-operative management. INTERVENTION: Each patient was monitored using near-infrared spectroscopy and EEG in addition to the routine peri-operative monitoring. Neurocardiovascular graphs were computed off-line. MAIN OUTCOME MEASURES: The primary endpoint was the difference in neurocardiovascular graph connectivity in the groups over time. RESULTS: Thirty-six patients were included. The intraoperative graph connectivity decreased in all patients operated upon in the operation room (OR) with sevoflurane-based anaesthesia ( P |
| Databáze: | OpenAIRE |
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