Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
| Autor: | Hee Jeong Jeong, Eunsoo Moon, Je-Min Park, Young-Min Lee, Young In Chung, Jae-Hong Park, Jeong-Hyun Park, Byung Dae Lee, YongJun Cheon, Yoonmi Choi, Byeong-Moo Choe |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cerebellum Quinpirole Bipolar disorder Hippocampus Hippocampal formation Open field 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Circadian rhythm Biological Psychiatry Protein kinase C Protein Kinase C business.industry 030227 psychiatry Open field test Psychiatry and Mental health Endocrinology medicine.anatomical_structure Original Article business 030217 neurology & neurosurgery Behavioural despair test medicine.drug |
| Zdroj: | Psychiatry Investigation |
| ISSN: | 1976-3026 1738-3684 |
| Popis: | Objective Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. Methods The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. Results The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. Conclusion These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern. |
| Databáze: | OpenAIRE |
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