Four Thousand Years of Concepts Relating to Rabies in Animals and Humans, Its Prevention and Its Cure
Autor: | Arnaud Tarantola |
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Přispěvatelé: | Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de Nouvelle-Calédonie |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment [SDV]Life Sciences [q-bio] Developing country rabies 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases vaccine Medicine 030212 general & internal medicine One Health Post-exposure prophylaxis Intensive care medicine General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Semple medicine.disease 3. Good health Regimen Galtier Roux 030104 developmental biology Infectious Diseases Pasteur Infectious disease (medical specialty) Immunology post-exposure prophylaxis dog Rabies history Rural area business Rabies in animals |
Zdroj: | Tropical Medicine and Infectious Disease Tropical Medicine and Infectious Disease, MDPI, 2017, 2 (4), pp.1-21. ⟨10.3390/tropicalmed2020005⟩ |
ISSN: | 2414-6366 |
Popis: | International audience; The epitome of the One Health paradigm—and of its shortcomings—rabies has been known to humankind for at least 4000 years. We review the evolution through history of concepts leading to our current understanding of rabies in dogs and humans and its prevention, as transmitted by accessible and surviving written texts. The tools and concepts currently available to control rabies were developed at the end of the 19th Century, including the first live, attenuated vaccine ever developed for humans and the first post-exposure prophylaxis (PEP) regimen. No progress, however, has been made in etiological treatment, leaving clinicians who provide care to animals or patients with symptomatic rabies as powerless today as their colleagues in Mesopotamia, 40 centuries ago. Rabies remains to date the most lethal infectious disease known to humans. Widespread access to timely, effective, and affordable PEP in rural areas of developing countries is urgently needed. |
Databáze: | OpenAIRE |
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