Dysregulation of lipid metabolism induced by airway exposure to polycyclic aromatic hydrocarbons in C57BL/6 mice
| Autor: | Chao Li, Jingguang Li, Binbin Xiang, Huiting Huang, Songlei Ren, Qian Luo, Yan Jin, Fang Li |
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| Rok vydání: | 2018 |
| Předmět: |
C57BL/6
Male medicine.medical_specialty Time Factors 010504 meteorology & atmospheric sciences Health Toxicology and Mutagenesis 010501 environmental sciences Toxicology 01 natural sciences chemistry.chemical_compound Mice Sex Factors Internal medicine Lipidomics medicine Benzo(a)pyrene Animals Humans Inducer Polycyclic Aromatic Hydrocarbons Lung cancer Lung 0105 earth and related environmental sciences Air Pollutants biology Chemistry Metabolic disorder Lipid metabolism General Medicine Lipidome medicine.disease biology.organism_classification Lipid Metabolism Pollution Lipids Mice Inbred C57BL Endocrinology Pyrene Female Biomarkers |
| Zdroj: | Environmental pollution (Barking, Essex : 1987). 245 |
| ISSN: | 1873-6424 |
| Popis: | Polycyclic aromatic hydrocarbons (PAHs), originated from cigarette smoke and fine particle matter (PM2.5), are important inducers of lung cancer. Lipid metabolic disorder is an important biological feature in the progression of lung cancer. However, the dysregulation of lipid metabolism induced by airway exposure to PAHs remains unknown. In this study, an untargeted lipidomics approach was performed to characterize the effects of airway exposure to benzo[a]pyrene (BaP) on lipid metabolism of C57BL/6 mice. Lipidome of serum samples were analyzed with an ultra-performance liquid chromatography coupled with quadrupole-orbitrap mass spectrometer. Lipid profiling and multivariate statistical analysis results demonstrated that airway exposure to BaP mainly disturbed glycerophospholipid metabolism of mice. Moreover, sex-dependent and time-dependent effects of BaP exposure on lipids profile of mice were observed. Several phosphatidylcholines (PCs), Lysophosphatidylcholines (LysoPCs), phosphatidylethanolamines (PEs), Lysophosphatidylethanolamines (LysoPEs) and phosphatidylinositols (PIs) were significantly down-regulated in mice serum after BaP exposure. Meanwhile, these altered lipids showed different susceptibility and change trends in male and female mice. Our results are corresponding with the lipid metabolic alterations induced by cigarette smoke and PM2.5 in animals or human. Compared with the dysregulation of lipid metabolism in patients with lung cancer, these results indicated that the lipid metabolism response to PAHs airway exposure may contribute to the lung cancer progression. |
| Databáze: | OpenAIRE |
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