Risk factors for hepatocellular carcinoma in patients with drug-resistant chronic hepatitis B
| Autor: | Min Woo Chung, Hyoung Ju Hong, Seon-Young Park, Hyun Soo Kim, Young Eun Joo, Sung Bum Cho, Chang-Hwan Park, Chung Hwan Jun, Sung Kyu Choi, Jong Sun Rew |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Liver Cirrhosis
Male Cirrhosis Kaplan-Meier Estimate medicine.disease_cause Gastroenterology Risk Factors Hepatitis B e Antigens biology Liver Neoplasms Age Factors General Medicine Hepatitis B Middle Aged Prognosis C-Reactive Protein HBeAg Hepatocellular carcinoma Female alpha-Fetoproteins Adult medicine.medical_specialty Hepatitis B virus Carcinoma Hepatocellular Genotype Brief Article Antiviral Agents Hepatitis B Chronic Internal medicine Drug Resistance Viral medicine Carcinoma Humans Seroconversion neoplasms Aged Neoplasm Staging Retrospective Studies Chi-Square Distribution business.industry C-reactive protein medicine.disease digestive system diseases Logistic Models Immunology Multivariate Analysis biology.protein business |
| Zdroj: | World journal of gastroenterology. 19(40) |
| ISSN: | 2219-2840 |
| Popis: | AIM: To investigate the risk factors and characteristics of hepatocellular carcinoma (HCC) in the patients with drug-resistant chronic hepatitis B (CHB). METHODS: A total of 432 patients with drug-resistant CHB were analyzed retrospectively from January 2004 to December 2012. The patients were divided into two groups: the HCC group (n = 57) and the non-HCC group (n = 375). Two groups compared using logistic regression for various patients and viral characteristics in order to identify associated risk factors for HCC. Secondarily, patient and tumor characteristics of HCC patients with naive CHB (N group, n = 117) were compared to the HCC group (R group, n = 57) to identify any difference in HCC characteristics between them. RESULTS: A significant difference was found for age, platelet count, alpha-fetoprotein (AFP), positivity of HBeAg, seroconversion rate of HBeAg, virologic response, the Child-Pugh score, presence of rtM204I, and the duration of antiviral treatment in non-HCC and HCC group. Cirrhosis, age (> 50 years), HBeAg (+), virologic non-responder status, and rtM204I mutants were independent risk factors for the development of HCC. The R group had lower serum C-reactive protein (CRP) and AFP levels, earlier stage tumors, and a shorter mean tumor surveillance period than the N group. However, the total follow-up duration was not significantly different between the two groups. CONCLUSION: 13.2% of patients with drug-resistant CHB developed HCC. Age, cirrhosis, YIDD status, HBeAg status, and virologic response are associated with risk of HCC. Patients with drug-resistant CHB and these clinical factors may benefit from closer HCC surveillance. |
| Databáze: | OpenAIRE |
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