Escherichia coli O157:H7–associated hemolytic-uremic syndrome after ingestion of contaminated hamburgers
| Autor: | John R. Brandt, Laurie Fouser, Ellis D. Avner, Sandra L. Watkins, Phillip I. Tarr, Valle Nazar-Stewart, Israel Zelikovic |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Washington medicine.medical_specialty ARDS Meat Adolescent medicine.medical_treatment Renal function Gastroenterology Disease Outbreaks Peritoneal dialysis chemistry.chemical_compound Internal medicine Escherichia coli Animals Humans Medicine Child Stroke Escherichia coli Infections Retrospective Studies Creatinine business.industry Respiratory disease Infant Colitis medicine.disease Surgery chemistry Child Preschool Hemolytic-Uremic Syndrome Pediatrics Perinatology and Child Health Pancreatitis Cattle Female Hemodialysis Gastrointestinal Hemorrhage business |
| Zdroj: | The Journal of Pediatrics. 125:519-526 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(94)70002-8 |
| Popis: | We conducted a retrospective analysis of 37 children with Escherichia coli O157:H7-associated hemolytic-uremic syndrome. The infection was traced to contaminated hamburgers at a fast-food restaurant chain. Within 5 days of the first confirmed case, the Washington State Department of Health identified the source and interrupted transmission of infection. Ninety-five percent of the children initially had severe hemorrhagic colitis. Nineteen patients (51%) had significant extrarenal abnormalities, including pancreatitis, colonic necrosis, glucose intolerance, coma, stroke, seizures, myocardial dysfunction, pericardial effusions, adult respiratory disease syndrome, and pleural effusions. Three deaths occurred, each in children with severe multisystem disease. At follow-up two children have significant impairment of renal function (glomerular filtration rate < 80 ml/min/per 1.73 Hm2); both of these children have a normal serum creatinine concentration. Hemolytic-uremic syndrome is the most common cause of acute renal failure in children, and this experience emphasizes the systemic nature of this disease. Clinicians should anticipate that multisystem involvement may occur in these patients, necessitating acute intervention or chronic follow-up. This outbreak of Hemolytic-uremic syndrome also highlights the microbiologic hazards of inadequately prepared food and emphasizes the importance of public health intervention in controlling Hemolytic-uremic syndrome. |
| Databáze: | OpenAIRE |
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