Human Papillomavirus Infection and Associated Cervical Disease in Human Immunodeficiency Virus–Infected Women: Effect of Highly Active Antiretroviral Therapy
| Autor: | Maria Angela Grasso, Gianluca Taccagni, Massimo Origoni, Adriano Lazzarin, Caterina Uberti-Foppa, Fabrizio Veglia, Elisabetta Mastrorilli, Davide Ferrari, Flavia Lillo, Sara Lodini |
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| Přispěvatelé: | Lillo, Fb, Ferrari, D, Veglia, F, Origoni, Massimo, Grasso, Ma, Lodini, S, Mastrorilli, E, Taccagni, G, Lazzarin, A, UBERTI FOPPA, Caterina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Cervicitis HIV Infections Biology Gastroenterology Virus Uterine Cervical Diseases Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Internal medicine medicine Humans Immunology and Allergy Sida Papillomaviridae Aged Cervical cancer Reverse-transcriptase inhibitor Papillomavirus Infections HPV infection virus diseases Middle Aged medicine.disease biology.organism_classification CD4 Lymphocyte Count Tumor Virus Infections Infectious Diseases DNA Viral Immunology Disease Progression HIV-1 Female Viral disease medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 184:547-551 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | To determine the effect of highly active antiretroviral therapy (HAART) on high-risk human papillomavirus (HR-HPV) infections and related cervical lesions, the virologic and cytologic markers of HPV infection were prospectively studied in 163 human immunodeficiency virus (HIV)‐infected women, including 27 untreated, 62 treated with reverse transcriptase inhibitors, and 74 treated with HAART. A high prevalence of both infections with HR-HPV types (68%) and squamous intraepithelial lesions (SILs; low grade, 20.2%; high grade, 6.2%) was observed. The risks of infection and disease were inversely correlated with CD4 cell counts (P p .015 and , respectively). During the observation period (mean, 15.4 months; range, 6‐24 P p .022 months), CD4 cell counts increased significantly only in subjects receiving HAART (P ! ). Persistence of HR-HPV infection and progression of SILs were comparable in the 3 .001 groups. These results indicate that, even in the era of HAART, HIV-infected women should be monitored carefully for the emergence of high-grade SILs and cervical cancer. |
| Databáze: | OpenAIRE |
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