Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the systemic inflammatory response syndrome (SIRS)
| Autor: | David F. Treacher, V A Gant, Sion M. Lewis, K A Brown, B H Davis, S S Qureshi |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Endothelium Neutrophils Immunology Inflammation Human Immunology Granulocyte Antibodies Pathogenesis Sepsis Cell Adhesion medicine Humans Immunology and Allergy Aged Whole blood CD64 business.industry Receptors IgG Middle Aged Flow Cytometry medicine.disease Systemic Inflammatory Response Syndrome Systemic inflammatory response syndrome medicine.anatomical_structure Endothelium Vascular medicine.symptom business |
| Zdroj: | Clinical and Experimental Immunology. 125:258-265 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.2001.01596.x |
| Popis: | SummaryEvidence is growing to suggest that the multiple organ damage of the systemic inflammatory response syndrome (SIRS) arises from the untoward activity of blood polymorphonuclear cells (PMNs), which upon activation acquire the IgG high affinity receptor, CD64. In the current study, flow cytometry was used to assess the prevalence of CD64-bearing PMNs and the intensity of expression of CD64 in whole blood samples from 32 SIRS patients, 11 healthy normal subjects and from eight non-SIRS patients in the intensive care unit (ICU). The percentage of PMNs expressing CD64 was higher in SIRS patients (mean 65%) than in non-SIRS patients (mean 42%; P |
| Databáze: | OpenAIRE |
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