| Autor: |
J J, López-Cano, M A, González-Cela-Casamayor, V, Andrés-Guerrero, M, Vicario-de-la-Torre, J M, Benítez Del Castillo, R, Herrero-Vanrell, I T, Molina-Martínez |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutics. 623:121948 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/j.ijpharm.2022.121948 |
| Popis: |
Self-emulsified osmoprotective ophthalmic microemulsions (O/A) were prepared by combining betaine/leucine, clusterin/oleanolic acid, and hyaluronic acid or Dextran. The microemulsions contained an internal oily phase (1.2%), an external aqueous phase (96.3%), cosolvents (1%), and surfactants (1.5%). Physicochemical characterization and in vivo and in vitro tolerance were analyzed. The formulations' osmoprotective in vitro activity was assayed in a hyperosmolar model in human corneal cells. Average internal phase sizes were 16-26 nm for the microemulsions including Dextran. Addition of hyaluronic acid increased the size range (25-39 nm). Addition of osmoprotectants did not change nanodroplet size. The formulations were isotonic (280-290 mOsm/L) with neutral pH (≈7) and zeta potential (-10 to 0 mV), low surface tension (≈35-40mN·m |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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