Comorbidities rather than older age define outcome in adult patients with tumors of the Ewing sarcoma family

Autor: Jana Käthe Striefler, Maren Schmiester, Franziska Brandes, Anne Dörr, Stefan Pahl, David Kaul, Daniel Rau, Eva‐Maria Dobrindt, Georgios Koulaxouzidis, Lars Bullinger, Sven Märdian, Anne Flörcken
Rok vydání: 2022
Předmět:
Zdroj: Cancer Medicine. 11:3213-3225
ISSN: 2045-7634
Popis: BACKGROUND: Ewing family of tumors (EFT) is rarely diagnosed in patients (pts) over the age of 18 years (years), and data on the clinical course and the outcome of adult EFT pts is sparse. METHODS: In this retrospective analysis, we summarize our experience with adult EFT pts. From 2002 to 2020, we identified 71 pts of whom 58 were evaluable for the final analysis. RESULTS: Median age was 31 years (18-90 years). Pts presented with skeletal (n = 26), and extra-skeletal primary disease (n =32). Tumor size was ≥8 cm in 20 pts and 19 pts were metastasized at first diagnosis. Between the age groups (≤25 vs. 26-40 vs. ≥41 years) we observed differences of Charlson comorbidity index (CCI), tumor origin, as well as type and number of therapy cycles. Overall, median overall survival (OS) was 79 months (95% confidence interval, CI; 28.5-131.4 months), and median progression-free survival (PFS) 34 months (95% CI; 21.4-45.8 months). We observed a poorer outcome (OS, PFS) in older pts. This could be in part due to differences in treatment intensity and the CCI (
Databáze: OpenAIRE
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