Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas
Autor: | Kunxiang Luo, Chuanhua Zheng, Guanglong Huang, Yiliang Meng, Tianshi Que, Qianli Tang, Peng Yan, Xiaoping Chen, Haineng Huang, Juxin Gong, Hongcheng Luo, Jia Liu, Huangde Fu, Rentong Hu, Qisheng Luo |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Adult Male Poor prognosis medicine.medical_treatment medicine.disease_cause Pathology and Forensic Medicine DEAD-box RNA Helicases 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Downregulation and upregulation Glioma medicine Biomarkers Tumor Humans Aged Aged 80 and over Chemotherapy DDX5 business.industry Brain Neoplasms Cell Biology Middle Aged medicine.disease Prognosis Up-Regulation Radiation therapy 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Disease Progression Immunohistochemistry Female Carcinogenesis business |
Zdroj: | Pathology, research and practice. 216(3) |
ISSN: | 1618-0631 |
Popis: | Recent researches indicated Ddx5 and Ddx17 play crucial roles in tumorigenesis. However, the study of Ddx5 and Ddx17 in glioma remains a little. Our study investigated their expression in glioma and evaluated its association with clinical factors and prognostic significance. The expression of Ddx5 and Ddx17 were both upregulated in glioma tissues compared to normal brain tissues, and a significant positive correlation between Ddx5 and Ddx17 expression was identified by statistical analysis. Immunohistochemical staining verified the expression of Ddx5 and Ddx17 in peritumoral zone was lower than that in core zone but higher than normal brain tissues. Moreover, the increased expression of Ddx5 and Ddx17 was markedly correlated with WHO Grade and histological type, and high Ddx5 and Ddx17 were found to be significantly associated with the worse overall survival of glioma patients. In additional, higher expression of both Ddx5 and Ddx17 predicted shorter clinical survival time for high-grade glioma patients with radiotherapy or with chemotherapy. In conclusion, overexpressed Ddx5 and Ddx17 are involved in the clinical progression and poor prognosis of glioma patients, suggesting that their upregulation can be used as a reliable clinical predictor for tumor diagnosis and to predict survival in patients with glioma. |
Databáze: | OpenAIRE |
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