CT2108A and B: New Fatty Acid Synthase Inhibitors as Antifungal Agents
| Autor: | Ursula Mocek, Ted L. Underiner, Sheldon E. Broedel, Gail E. McElhaney-Feser, Robert E. Raulli, Jodi A. Laakso, Paul Actor, Brian J. Hotovec, Ronald L. Cihlar |
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| Rok vydání: | 2003 |
| Předmět: |
Wyoming
Antifungal Agents Stereochemistry Metabolite Pharmaceutical Science Saccharomyces cerevisiae Biology Analytical Chemistry Penicillium solitum Inhibitory Concentration 50 chemistry.chemical_compound Candida albicans Drug Discovery Humans Benzopyrans Enzyme Inhibitors Nuclear Magnetic Resonance Biomolecular Pyrans Pharmacology chemistry.chemical_classification Molecular Structure Organic Chemistry Penicillium Biological activity biology.organism_classification Fatty acid synthase Enzyme Complementary and alternative medicine Biochemistry chemistry Enzyme inhibitor Fermentation biology.protein Epoxy Compounds Molecular Medicine Fatty Acid Synthases |
| Zdroj: | Journal of Natural Products. 66:1041-1046 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np030046g |
| Popis: | A systematic screen for new natural products that displayed antifungal activity by inhibition of fungal fatty acid synthase (FAS) led to the discovery of two new fungal metabolites, designated CT2108A (1) and CT2108B (2). The metabolites were produced by Penicillium solitum (Westling) strain CT2108 and were classified as azaphilones. The structures of these new metabolites were determined using a variety of 1D and 2D NMR experiments, including COSY, HMQC, and HMBC. The chemical conversion of CT2108A to CT2108B was effected using WCl(6). The related metabolite, patulodin (3), was also isolated from the fermentation culture of this P. solitum isolate. Both new compounds inhibited fungal FAS, and neither was found to significantly inhibit human FAS activity. |
| Databáze: | OpenAIRE |
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