Management of Peritoneal Carcinomatosis With Cytoreductive Surgery Combined With Intraperitoneal Chemohyperthermia at a Novel Italian Center
| Autor: | Laura Boldrini, A Gadducci, Pinuccia Faviana, Lorenzo Fornaro, Alfonso Greco, Sergio Ricci, Mauro Ferrari, Augusto Brogi, Piero Vincenzo Lippolis, B Musco, Fulvio Basolo, Gianluca Masi, Alfredo Falcone, Francesco Forfori |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Colorectal cancer Disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Disseminated disease Peritoneal Neoplasms Retrospective Studies Pharmacology Cisplatin business.industry Cancer Cytoreduction Surgical Procedures Hyperthermia Induced medicine.disease Combined Modality Therapy Survival Rate Italy 030220 oncology & carcinogenesis Quality of Life Hyperthermic intraperitoneal chemotherapy Female Ovarian cancer business medicine.drug Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 |
| Popis: | Background Peritoneal carcinomatosis (PC) is a common manifestation of many gastrointestinal (GI) malignancies and is an advanced stage that is often associated with disseminated disease. Considerable progress has been made to achieve safe elimination of macroscopic disease using cytoreductive surgery (CRS) and more recently in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of microscopic disease or disease with minimal volume. The aim of this study was to assess the effects of such procedures on the quality of life (QoL), the long-term benefit and the functional status of the treated patients. Patients and methods Data from patients who underwent CRS-HIPEC for peritoneal metastasis (PM) at our center from November 2016 to November 2018 were analyzed retrospectively. The drugs administered were mitomycin and cisplatin. Quality of life (QoL) was assessed using the Euroquol-5D-5L and National Comprehensive Cancer Network Functional Assessment of Cancer Therapy-Breast Cancer Symptom Index v2 questionnaires before CRS-HIPEC, and 1, 3 and 6 months after were administered. Results In our series, the survival efficacy of CRS plus HIPEC was confirmed in the treatment of primary and secondary peritoneal pathologies, particularly in ovarian cancer, although larger studies are needed to investigate its role in the pathology of gastric, colonic and rectal cancer. The QoL data were promising, with essentially stable values between the preoperative and the 1-month follow-up, but with incremental benefits from the second to the third month. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|