Epigenetic regulation of mammalian genomic imprinting

Autor: Robert Feil, Katia Delaval
Přispěvatelé: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Rok vydání: 2004
Předmět:
GTPase-activating protein
Genetic/*physiology GTP-Binding Proteins/genetics GTPase-Activating Proteins Gene Expression Regulation/physiology Genomic Imprinting/*physiology Insulin-Like Growth Factor II/genetics Mice Receptor
IGF Type 2/genetics Repressor Proteins
DNA-binding protein
Receptor
IGF Type 2
Epigenesis
Genetic
Genomic Imprinting
Mice
03 medical and health sciences
0302 clinical medicine
GTP-Binding Proteins
Insulin-Like Growth Factor II
Genetics
Polycomb-group proteins
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Epigenetics
Imprinting (psychology)
030304 developmental biology
0303 health sciences
biology
GTPase-Activating Proteins
Animals DNA-Binding Proteins Epigenesis
DNA-Binding Proteins
Repressor Proteins
Histone
Gene Expression Regulation
DNA methylation
biology.protein
Genomic imprinting
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Current Opinion in Genetics and Development
Current Opinion in Genetics and Development, Elsevier, 2004, 14 (2), pp.188--95. ⟨10.1016/j.gde.2004.01.005⟩
ISSN: 0959-437X
1879-0380
DOI: 10.1016/j.gde.2004.01.005
Popis: Imprinted genes play important roles in development, and most are clustered in large domains. Their allelic repression is regulated by 'imprinting control regions' (ICRs), which are methylated on one of the two parental alleles. Non-histone proteins and nearby sequence elements influence the establishment of this differential methylation during gametogenesis. DNA methylation, histone modifications, and also polycomb group proteins are important for the somatic maintenance of imprinting. The way ICRs regulate imprinting differs between domains. At some, the ICR constitutes an insulator that prevents promoter-enhancer interactions, when unmethylated. At other domains, non-coding RNAs could be involved, possibly by attracting chromatin-modifying complexes. The latter silencing mechanism has similarities with X-chromosome inactivation.
Databáze: OpenAIRE
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