Rosette-forming glioneuronal tumor — evidence of stem cell origin with biphenotypic differentiation
| Autor: | H. R. Aravinda, Somanna Sampath, Aparna Govindan, T C Yasha, Susarla K. Shankar, Vani Santosh, A. A. Phalguni, S. Dwarakanath, A. Bhateja, Anita Mahadevan, Shrijeet Chakraborti, P. Rout |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Fourth ventricle Pathology and Forensic Medicine Ganglioglioma Immunoenzyme Techniques Young Adult Glioneuronal tumor Biomarkers Tumor medicine Humans Child Molecular Biology Microscopy Confocal biology Brain Neoplasms Rosette (schizont appearance) Cell Biology General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Phenotype Neoplastic Stem Cells Synaptophysin biology.protein Immunohistochemistry Female Stem cell Who classification |
| Zdroj: | Virchows Archiv. 461:581-588 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-012-1313-0 |
| Popis: | Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a new addition to the WHO classification of central nervous system tumors. To date, 72 cases have been described in literature. In the present study, we report the clinical and imaging features, with detailed histopathological and immunohistochemical profile, of eight cases. Confocal microscopic evidence of stem cell origin with biphenotypic, glial and neurocytic differentiation is presented with a comprehensive review of literature. |
| Databáze: | OpenAIRE |
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