Maternal serum human chorionic gonadotropin level at fifteen weeks is a predictor for preeclampsia
| Autor: | Françoise Muller, Laurence Bussières, Lionel Savey, Jean Claude Colau, Gérard Ndayizamba, Paul Giraudet, Bernard Le Fiblec |
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| Rok vydání: | 1996 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Intrauterine growth restriction Chorionic Gonadotropin Sensitivity and Specificity Preeclampsia Human chorionic gonadotropin Pre-Eclampsia Pregnancy medicine Humans reproductive and urinary physiology Retrospective Studies Obstetrics business.industry Infant Newborn Obstetrics and Gynecology medicine.disease Infant Small for Gestational Age embryonic structures Gestation Female Amenorrhea medicine.symptom Gonadotropin Trisomy business Biomarkers |
| Zdroj: | American Journal of Obstetrics and Gynecology. 175:37-40 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(96)70247-8 |
| Popis: | Our purpose was to study the correlation between maternal serum human chorionic gonadotropin levels measured at 15 to 18 weeks of amenorrhea and pregnancy-induced hypertension, preeclampsia, and small-for-gestational-age neonates.Prospective trisomy 21 human chorionic gonadotropin screening data from 5776 patients were examined in a retrospective investigation of the relationship between human chorionic gonadotropin and pregnancy-induced hypertension (234 cases), preeclampsia (34 cases), and small-for-gestational-age neonates (238 cases).Maternal serum human chorionic gonadotropin (multiples of the median) was higher in the three populations with pathologic disorders. This difference was statistically significant in patients with small-for-gestational-age neonates (p0.0163) and preeclampsia (p0.0001) but not in those with pregnancy-induced hypertension. In the preeclampsia subgroup, with a cutoff value of 2 multiples of the median, specificity was 32% and sensitivity was 10%; with a cutoff value of 1 multiples of the median, specificity was 100% and sensitivity was 50%.High maternal serum human chorionic gonadotropin levels at 15 weeks are related to a risk for preeclampsia. Depending on the human chorionic gonadotropin cutoff value, 32% or 100% of preeclampsia patients would be selected. The usefulness of preventive aspirin treatment from the fifteenth week needs more investigation in a larger multicenter study of preeclampsia. |
| Databáze: | OpenAIRE |
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