Amylopectin Starch Induces Nonreversible Insulin Resistance in Rats
| Autor: | Janine A. Higgins, Janette Brand Miller, Gareth Denyer, C. E. Wiseman |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Diet therapy Starch medicine.medical_treatment Amylopectin Medicine (miscellaneous) Biology Polysaccharide Random Allocation chemistry.chemical_compound Insulin resistance Amylose Internal medicine medicine Animals Insulin Rats Wistar chemistry.chemical_classification Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test food and beverages Glucose Tolerance Test medicine.disease Rats Glucose Endocrinology chemistry Biochemistry Insulin Resistance |
| Zdroj: | The Journal of Nutrition. 126:410-415 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/126.2.410 |
| Popis: | Starches that are high in amylopectin are digested and absorbed more quickly than starches with a high amylose content and produce insulin resistance in rats during long-term feeding. The aim of this study was to determine whether amylopectin-induced insulin resistance could be prevented or reversed by a period of high amylose feeding. We employed a randomized design in which two groups of rats were fed either the high amylose and then the high amylopectin diet for two consecutive 8-wk periods or vice versa (high amylopectin and then high amylose). Four other groups were fed either a high amylose or a high amylopectin diet for 8 or 16 wk. All rats were fed two 10-g meals per day (300 kJ/d), and insulin sensitivity was assessed by intravenous glucose tolerance test (IVGTT) after 8 or 16 wk of feeding. We found no difference in glucose tolerance between any group at any time point. Insulin responses, however, were 50% higher (P < 0.01) after 16 wk of high amylopectin feeding [area under the plasma insulin curve (AUC) = 18.1 +/- 1.4 nmol.L-1 x 15 min] compared with high amylose feeding (AUC = 13.0 +/- 1.2 nmol.L-1 x 15 min). The two groups which received both diets developed a similar degree of insulin resistance, equivalent to that after 16 wk of high amylopectin feeding. The findings suggest that amylopectin-induced insulin resistance cannot be reversed or prevented by either a subsequent or previous period of amylose feeding. Taken together, the data suggest that the nature of starch in the Western diet influences the development of noninsulin-dependent diabetes mellitus in humans. |
| Databáze: | OpenAIRE |
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