Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level
| Autor: | Faizah Othman, Farida Hussan, C L G Chong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Statin Article Subject medicine.drug_class Adipose tissue Inflammation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Diseases of the circulatory (Cardiovascular) system biology business.industry biology.organism_classification medicine.disease 030104 developmental biology Endocrinology Morinda Simvastatin RC666-701 Ovariectomized rat medicine.symptom Cardiology and Cardiovascular Medicine business Dyslipidemia Lipoprotein medicine.drug |
| Zdroj: | International Journal of Vascular Medicine, Vol 2018 (2018) |
| ISSN: | 2090-2824 |
| DOI: | 10.1155/2018/6317434 |
| Popis: | Atherosclerosis is now well understood as an inflammatory disease instead of lipid storage disorder; however, the conventional treatment is not targeted on treating the inflammation. Morinda citrifolia L. (Rubiaceae) leaf or noni leaf, which is a medicinal food (ulam) used in Traditional Malay Medicine to prevent chronic diseases, may have the potential to be formulated into a functional antiatherosclerotic agent. This study aimed to investigate the effectiveness of Morinda citrifolia leaf extract (MCLE) treatment at histological and ultrastructural level, comparing it with Simvastatin. Thirty-eight female Sprague Dawley rats were divided into five groups: Sham (Sham), ovariectomized (OVX), ovariectomized with Simvastatin 10 mg/kg (OVX+ST), ovariectomized with low dose MC 500 mg/kg (OVX+MCLD), and ovariectomized with high dose MC 1000 mg/kg (OVX+MCHD). Atherosclerosis was induced by producing oestrogen deficiency through ovariectomy and feeding with thermoxidized palm oil (TPO) diet for 12 weeks along with the treatment. The results revealed significantly (P |
| Databáze: | OpenAIRE |
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