Gut microbiota: implications for radiotherapy response and radiotherapy-induced mucositis
| Autor: | Ysabella Z.A. Van Sebille, Hien Le, Ghanyah H. Al-Qadami, Joanne M. Bowen |
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| Přispěvatelé: | Al-Qadami, Ghanyah, Van Sebille, Ysabella, Le, Hien, Bowen, Joanne |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
Oncology medicine.medical_specialty Tissue toxicity medicine.medical_treatment Treatment outcome Gut flora immunomodulation Radiation Tolerance Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Neoplasms Internal medicine medicine Mucositis microbiota Animals Humans Intestinal Mucosa Radiation Injuries Solid tumor radiotherapy Stomatitis Radiotherapy Hepatology biology business.industry fungi Mouth Mucosa Gastroenterology food and beverages biology.organism_classification medicine.disease Gastrointestinal Microbiome Radiation therapy mucositis 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business |
| Popis: | Introduction: Radiotherapy is a mainstay of solid tumor management but can be associated with unacceptable levels of off-target tissue toxicity which impact treatment outcomes and patients’ quality of life. Tumour response to radiotherapy and the frequency and severity of radiotherapy-induced toxicities, especially mucositis, varies among patients. Gut microbiota has been found to modulate both the efficacy and toxicity of some types of cancer chemotherapies and immunotherapies but has yet to be investigated thoroughly in the setting of radiotherapy. Area covered: In this review, we discuss the potential role of gut microbiota on modulating radiotherapy-induced oral and gastrointestinal mucositis and the anti-tumor response to radiotherapy through modulation of immune responses. Expert opinion: The gut microbiota plays a major role in the modulation of systemic immune responses,which influence both radiotherapy response and gastrointestinal toxicities such as mucositis. Hence,investigating the gut microbiota link to the variation in radiotherapy responses and toxicities among patients is warranted. Future targeting of these responses with a patient-tailored restoration of optimal microbial composition could lead to a new era of mucositis prevention and enhanced tumor responses. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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